Acute Pancreatitis Induced by Quetiapine in an Elderly Patient

Lee, Hak Chul; Choi, Jongkyoung; Koh, Jung A; Kim, Seon Jae; Chu, Seong Taek; Kim, Si Eun; Choi, Seung Kyu; Nam, Seung Woo; Kwon, Hyuk Chun; Jung, Ju Won; Jung, In A

doi:2015.19.3.176

Ann Geriatr Med Res > Volume 19(3); 2015 > Article

Case Report

Journal of the Korean Geriatrics Society 2015;19(3):176-180.
DOI: https://doi.org/10.4235/jkgs.2015.19.3.176 Published online September 30, 2015.

Acute Pancreatitis Induced by Quetiapine in an Elderly Patient

Hak Chul Lee, Jongkyoung Choi, Jung A Koh, Seon Jae Kim, Seong Taek Chu, Si Eun Kim, Seung Kyu Choi, Seung Woo Nam, Hyuk Chun Kwon, Ju Won Jung, In A Jung

Department of Internal Medicine, National Medical Center, Seoul, Korea. cjk@nmc.or.kr

노인 환자에서 Quetiapine에 의해 발생한 급성췌장염 1예

이학철, 최종경, 고정아, 김선재, 주성택, 김시은, 최승규, 남승우, 권혁춘, 정주원, 정인아

국립중앙의료원 내과

Abstract

Quetiapine is an atypical antipsychotic that is frequently used to manage delirium in geriatric patients. Acute pancreatitis associated with quetiapine has rarely been reported. A 70-year-old male presented with severe abdominal pain a few hours after taking a dose of quetiapine prescribed for delirium. Despite the lack of risk factors of pancreatitis in his medical history, the patient had a slight increase of serum lipase and amylase levels. His general condition improved on discontinuation of quetiapine. A month later, quetiapine was readministered for the recurrence of delirium. Subsequently, the patient developed the same symptom with a significant increase in serum pancreatic enzyme levels, confirming that quetiapine induced the pancreatitis. We reported the first case of quetiapine-induced pancreatitis in Korea, together with a review of the literature.

Key Words: Acute pancreatitis, Quetiapine, Delirium