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Ann Geriatr Med Res > Volume 17(2); 2013 > Article
Journal of the Korean Geriatrics Society 2013;17(2):99-102.
DOI: https://doi.org/10.4235/jkgs.2013.17.2.99    Published online June 30, 2013.
Severe Resistant Hypertension Induced by Carbamazepine in an Elderly Patient
Seon Jae Kim, Jung A Koh, Hak Chul Lee, Si Eun Kim, Seong Taek Chu, Seung Hun Lee, Jung Ju Sir, Seung Min Choi, Shin Bae Joo, Hong Soon Lee, Dae Hee Han
1Department of Internal Medicine, National Medical Center, Seoul, Korea. seo0515@medimail.co.kr
2Department of Cardiovascular Center, National Medical Center, Seoul, Korea.
3Department of Neurosurgery, National Medical Center, Seoul, Korea.
노인 환자에서 carbamazepine에 의해 발생한 저항성 고혈압 1례
김선재1,2·고정아1,2·이학철1,2·김시은1,2·주성택1,2·이희숙1,3·이승훈1,2·서정주1,2·최승민1,2·주신배1,2 이홍순1,2·한대희3
국립중앙의료원 순환기내과1, 심혈관센터2, 신경외과3
We report a case of a 73-year-old patient with a 17 year-history of well-controlled primary hypertension with a single antihypertensive drug, which became uncontrolled since 9 months ago when he started on oral carbamazepine (CBZ) therapy for syringomyelia. On admission, the patient had a blood pressure of 200-215/95-104mmHg despite an antihypertensive combination therapy with five different drugs. Further investigations ruled out secondary hypertension such as primary aldosteronism, pheochromocytoma and renal artery stenosis. After the discontinuation of CBZ, the blood pressure profile became significantly improved. The rechallenge with CBZ aggravated his blood pressure profile. Therefore, we considered that resistant hypertension was induced by the oral CBZ therapy.
Key Words: Carbamazepine, Hypertension, Tricyclic antidepressants

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