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Journal of the Korean Geriatrics Society 2003;7(4):305-312.
Published online December 31, 2003.
Relationship between Metabolic Syndrome and Coronary Heart Disease in Elderly
Young Jin Kim, Do Kyun Kim, Jeon Su Ryu, Woo Seob Eom, Jae Hyun Cho, Young Jung Cho, Hong Woo Nam, Sin Bae Joo
65세 이상의 노인 환자에서 대사증후군과 관상동맥질환과의 관계
Abstract
BACKGROUND
Metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, over- weight and abdominal fat distribution, dyslipidemia and hypertension, is associated with subsequent de- velopment of type 2 diabetes mellitus and cardiovascular disease, especially coronary heart disease. The aim of the study is to assess the relationship between metabolic syndrome and coronary heart disease in elderly greater than 65 years old.
METHODS
Eighty two elderly patients greater than 65 years old who underwent coronary angiography were divided into two groups with metabolic syndrome or without metabolic syndrome, and assessed the association with coronary angiographic finding. The metabolic syndrome factors and cardiovascular risk factors of JNC 7 were investigated to assess the relationship with coronary heart disease in elderly. Coronary heart disease was defined as 50% or greater diameter in stenosis of coronary artery in coronary angiography.
RESULTS
In elderly patients with metabolic syndrome, coronary angiographically abnormal findings(p<0.05) and multi vessel disease findings(p<0.05) were presented significantly higher than non metabolic syndrome patients. In elderly patients with 3 and more cardiovascular risk factors of JNC 7, coronary angiographically abnormal findings(p<0.05) and multi vessel disease findings(p=0.059) were presented more than the other patients. Diabetes mellitus was related significantly with coronary heart disease(p value 0.044).
CONCLUSION
In elderly patients, metabolic syndrome was significantly related with coronary heart disease and diabetes mellitus had strong relationship with coronary heart disease. Metabolic syndrome and cardiovascular risk factors of JNC 7 should be further evaluated to assess the relationship with coronary heart disease in the future.
Key Words: Metabolic syndrome, Coronary heart disease, Coronary angiographic findings, Cardiova-scular risk factors of JNC 7


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