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Ann Geriatr Med Res > Volume 20(2); 2016 > Article
Journal of the Korean Geriatrics Society 2016;20(2):78-84.
DOI: https://doi.org/10.4235/jkgs.2016.20.2.78    Published online June 30, 2016.
The Effectiveness of Lean Body Mass Analysis Using Dual Energy X-ray Absorptiometry for Diagnosis of Sarcopenia: Systematic Review
So Young Kim, Sun Young Park
National Evidence-based Healthcare Collaborating Agency
근감소증 진단을 위한 이중에너지 방사선 흡수계측법을 이용한 제지방 분석의 유효성: 체계적 문헌고찰
김소영<sup>1</sup>, 박선영<sup>1</sup>
한국보건의료연구원
Abstract
BACKGROUND
This study aimed to evaluate the effectiveness of lean body mass analysis using dual-energy X-ray absorptiometry (DEXA) for diagnosing sarcopenia.
METHODS
We conducted a systematic review by searching eight Korean databases and international databases, including Ovid-MEDLINE, Embase, and Cochrane Library. Twenty-five studies using DEXA were included in the final assessment. Two reviewers independently assessed the quality of the included studies and extracted data. The quality of the studies was assessed according to the Scottish Intercollegiate Guidelines Network tool.
RESULTS
The effectiveness of lean body mass analysis using DEXA was assessed by means of correlations with comparators, relevance to clinical symptoms, and forecasting of prognosis. The correlations with comparators (magnetic resonance imaging, computed tomography, bioelectrical impedance analysis, and anthropometry) took different positions. The risk ratio (RR) or odds ratio (OR) of the decrease in physical functions was 0.57-2.48, and the RR of osteoporosis was 1.15-9.4. The hazard ratio of death was 1.24-3.12, OR of cardiovascular disease was 1.768, and RR of survival was 0.85.
CONCLUSION
Lean body mass analysis using DEXA for diagnosing sarcopenia seems promising, but more studies are needed to clarify the diagnostic criteria for sarcopenia and cut-off for DEXA.
Key Words: Sarcopenia, Lean body mass, Fat free mass, Dual-energy X-ray absorptiometry
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