| Geriatric nutritional risk index as a possible predictor of decline in kidney function in older people |
Sukmin Yoon1, Nak Gyeong Ko2, Yu-Ji Lee1 
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1Division of Nephrology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
2Department of Research & Support, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea |
Correspondence:
Yu-Ji Lee,
Email: yuji.lee@samsung.com
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Received: 27 December 2023 • Revised: 30 January 2024 • Accepted: 24 February 2024 |
| Abstract |
Background
The Geriatric Nutritional Risk Index (GNRI) is associated with morbidity and mortality in older individuals. Our study explored the relationship between GNRI, decline in kidney function, and all-cause mortality in older individuals.
Methods
This retrospective cohort study analyzed data from participants aged ≥60 years who underwent a general health checkup between 2002 and 2018. The primary exposure was the GNRI, divided into quartiles. The primary and secondary outcomes were a decline in kidney function assessed using the five-year estimated glomerular filtration rate (eGFR) and all-cause mortality, respectively.
Results
The analysis included a total of 1,599 participants (median [interquartile range] age, 63 (61–67) years; 54% males). The mean ± standard deviation (SD) of GNRI was 114 ± 7. Compared with the highest GNRI quartile, the lower GNRI quartiles were associated with steeper five-year slopes in eGFR, with a fully adjusted beta coefficient and 95% confidence intervals (CIs) of −0.50 (−0.86. −0.14), −0.29 (−0.63. 0.05), and −0.19 (−0.53. 0.14) for the first, second, and third GNRI quartiles, respectively. The median follow-up duration was 7.4 (4.6–12.4) years. During this period, we identified 108 deaths (7.8 per 1000 person-years). The first GNRI quartile was associated with all-cause mortality compared to the highest GNRI quartile (hazard ratio and 95%CI 2.20 [1.23, 3.95]).
Conclusion
Nutritional status, as evaluated using the GNRI, was associated with five-year changes in kidney function and all-cause mortality in older individuals. |
| Key Words:
older individual, kidney function, mortality, nutrition |
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