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Journal of the Korean Geriatrics Society 2004;8(2):104-109.
Published online June 30, 2004.
The Role of Carotid Atheroscleros is in the Distinction BetweenIs chemic and Non-is chemic Cardiomyopathy
Yung Woo Shin
Department of Int ernal Medicine, Pusan University College of Medicine, Pusan, Korea. pnuhshin@hanmail.net
허혈성과 비허혈성 심근증의 감별에 경동맥경화증의 역할
Abstract
BACKGROUND
S: Ischemic cardiomyopathy in the elderly bears a worse prognosis than non-ischemic cardiomyopathy, and may show an improved outcome after myocardial revascularization. The noninvasive techniques which can reliably distinquish between ischemic and non-ischemic cardiomyopathy have been tested. As ultrasonographically assessed carotid atherosclerosis is being used as a surrogate measure of coronary atherosclerosis, non studies to date have used carotid atherosclerosis to distinguish between ischemic and non-ischemic cardiomyopathy in the elderly.
METHODS
One hundred forty eight patients(61 women, 87 male) greater than 65 years of age who have dilated cardiomyopathy with left ventricular enddiastolic inner dimension 55mm and fractional shortening 25% were evaluated by B-mode ultrasound imaging of carotid artery for measurement of atherosclerotic plaque. Also coronary angiography was done, and ischemic cardiomyo- pathy was defined as the presence of any 2 or more epicardial coronary vessels with 75% stenosis. and then the value of carotid athe rosclerosis in the distinction between ischemic and non-ischemic etiology in the elderly with dilated cardiomyopathy was examined.
RESULTS
Ischemic etiology of dilated cardiomyopathy in the elderly can be defined as the presence of carotid atherosclerosis with 25% stenosis. Carotid stenosis 25% had sensitivity 82.5%(74% in women, 91% in male), specificity 85.5%(92% in women, 79% in male), positive predictive value 90.5%(93% in women, 88% in male) and negative predictive value 78.5%(73% in women, 84% in male) as whole in the identification of patients with ischemic cardiomyopathy.
CONCLUSION
Carotid stenosis by B-mode ultrasonography is noninvasive and useful in the distinction between ischemic and nonischemic etiology in the elderly patients with clinically unexplained cardiomyopathy
Key Words: Ischemic cardiomyopathy, Non-ischemic Cardiomyopathy, Carotid atherosclerosis
초 록

연구배경: 노인에서 허혈성 심근증은 예후가 불량하고, 혈관재건술로 호전될 수 있어 비허혈성 심근증과 감별이 필요하며, 유용한 비침습적 감별법이 요망되고 있다. 경동맥경화증은 관동맥경화증을 추정하는 지표로 인정받고 있지만, 노인에서 경동맥경화도가 가지는 허혈성과 비허혈성 심근증의 감별능에 대한 연구는 없는 실정이다.

방법: 좌심실 확장기말 내경이 55 mm 이상이고 분획단축률이 25% 이하인 확장형 심근증을 가진 65세 이상 노인 148예(여자 61예, 남자 87예)를 대상으로 경동맥 B형 초음파 검사를 시행하여 경동맥경화도를 계측하였다. 아울러 관동맥촬영을 시행하여 75% 이상의 직경 협착도를 가진 2혈관 또는 3혈관 질환자는 허혈성 심근증으로 규정하였다. 이를 근거하여 경동맥경화도에 따른 허혈성과 비허혈성 심근증의 판별력을 분석하였다.

결과: 경동맥경화증의 직경 협착도 25%를 기준하여 허혈성과 비허혈성 심근증을 판별할 수 있으며, 이 경우의 예민도는 82.5%(여자는 74%, 남자는 91%), 특이도가 85.5%(여자는 92%, 남자는 79%), 양성 예측치는 90.5%(여자는 93%, 남자는 88%), 음성 예측치는 78.5%(여자는 73%, 남자는 84%)였다.

결론: 비침습적 경동맥 B형 초음파 검사를 사용하여 측정한 경동맥경화증의 중정도는 노인에서 허혈성과 비허혈성 심근증을 판별하는데 신뢰성이 있고 유용한 지표이다.

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