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Ann Geriatr Med Res > Volume 19(1); 2015 > Article
Journal of the Korean Geriatrics Society 2015;19(1):34-39.
DOI: https://doi.org/10.4235/jkgs.2015.19.1.34    Published online March 31, 2015.
Hyperinsulinemic Hypoglycemia Caused by Acute Reduction of Renal Function on an Eldery Patient Without Diabetes
Jee Hyun Yeo, Jeong Eun Kim, Eun Sik Park, Jung Hwan Park, Dong Sun Kim, Woong Hwan Choi, Yoo Hun Ahn, Ho Joong Kim, Sang Mo Hong, Chang Beom Lee
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. lekang@hanyang.ac.kr
당뇨병이 없는 노인 환자에서 급성 신기능 감소와 동반된 고인슐린혈증성 저혈당이 발생한 1예
여지현 ⦁ 김정은 ⦁ 박은식 ⦁ 박정환 ⦁ 김동선 ⦁ 최웅환 ⦁ 안유헌 ⦁ 김호중 ⦁ 홍상모 ⦁ 이창범
한양대학교 의과대학 내과학교실
In patient with renal failure, hypoglycemia may develop because of decreased caloric intake, diminished renal insulin degradation and clearance, reduced renal gluconeogenesis and hepatic glucose production, impaired release of counter-regulatory hormone such as glucagon and epinephrine. We report here on a 80-year-old female patient with hypoglycemia due to endogenous hyperinsulinemia with acute kidney injury. She had chronic kidney disease and had no history of diabetes mellitus or insulin use. She had experienced recurrent hypoglycemia despite of intravenous dextrose injection and eventually generalized tonic clonic seizure occurred as a result of hypoglycemia. As serum creatinine level decreases, serum insulin and C-peptide level decreased and hypoglycemia was not occurred. We present this case along with a review of the literature.
Key Words: Acute renal injury, Hypoglycemia, Hyperinsulinemia
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