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Ann Geriatr Med Res > Volume 14(3); 2010 > Article
Journal of the Korean Geriatrics Society 2010;14(3):121-130.
DOI: https://doi.org/10.4235/jkgs.2010.14.3.121    Published online September 30, 2010.
Investigation of Sarcopenia and Its Association with Cardiometabolic Risk Factors in Elderly Subjects
Jung Hee Kim, Yul Hwang Bo, Eun Shil Hong, Jung Hun Ohn, Chi Hoon Kim, Hye Won Kim, Hwa Young Ahn, Ji Won Yoon, Seon Mee Kang, Young Joo Park, Hak Chul Jang, Soo Lim
1Department of Internal Medicine, Seoul National University of College of Medicine, Seoul, Korea. limsoo@snu.ac.kr
2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
노인 인구에서 근감소증과 심혈관계 대사질환 위험인자와의
연관성 조사
장학철1,2,임 수1,2
서울대학교 의과대학 내과학교실1, 분당서울대학교병원 내과학교실2
The aim of this study was to investigate sarcopenia and its association with cardiometabolic risk factors in a community-based elderly cohort in Korea.
We recruited 287 men and 278 women aged 65 years or older and without physical disability. Appendicular skeletal muscle mass (ASM) was measured with dual energy X-ray absorptiometry. We used two definitions for sarcopenia-ASM divided by height2 (kg/m2) or by weight (%) <1 SD below the sex-specific mean for young adults. We compared RBP-4, adiponectin, hsCRP, lipid profiles, and insulin resistance between the sarcopenic and normal groups using ASM/Ht2 and ASM/Wt.
The prevalence of sarcopenia was 35.3% in men and 13.4% in women with sarcopenia defined by ASM/Ht2. However, it was 38.3% in men and 62.6% in women by ASM/Wt. In correlation analysis, body mass index was positively correlated with ASM/Ht2 and negatively correlated with ASM/Wt. The sarcopenic group, when defined as ASM/Ht2, showed lower RBP4, fasting plasma glucose, and HOMA-IR and higher adiponectin than the normal group but not significantly different lipid profiles. The sarcopenic group defined by ASM/Wt had higher RBP4, fasting plasma glucose, and HOMA-IR, and lower adiponectin than the normal group in both sexes. Only in the males did the sarcopenic group defined by ASM/Wt reveal higher total cholesterol, triglycerides, and LDL cholesterol, and lower HDL cholesterol than the normal group.
In conclusion, the sarcopenic group defined by ASM/Wt was more closely associated with cardiometabolic risk factors than the normal group in a community-based elderly cohort.
Key Words: Sarcopenia, Cardiometabolic risk factors, Elderly

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