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Ann Geriatr Med Res > Volume 23(4); 2019 > Article
Lee, Lee, and Jang: Air Pollutants and Frailty in Older Adults: A Geriatrician’s Perspective
Many studies have provided evidence that air pollutants are harmful to humans.1-3) Emerging data and literature from South Korea support the relationship between air pollutants and healthcare expenditure and the threat of even ambient air pollution to mortality, morbidity, and various adverse health outcomes and quality of life.4) Through monthly balanced data using fixed and random-effect models, this study demonstrated the contributions of 5 common air pollutants to healthcare expenditure in 16 cities and provinces over 8 years (January 2010 to September 2017). The study also showed how each air pollutant affected healthcare expenditures in a particular population. Led by economists and not physicians, these findings emphasized the association between air pollutants and healthcare expenditures, indicating the urgent need for policymakers to develop effective healthcare policies.
The authors not only presented a systematic analysis of healthcare expenditure but also categorized the healthcare costs by region, demographic structure, and specific diseases.4) One interesting aspect was their presentation of the regional minimum and maximum per-patient healthcare expenditures. The authors showed that a higher personal income level leads to higher healthcare expenditure and that per-patient healthcare expenditure increases with population age. As in other countries, older adults in South Korea are the population most vulnerable to air pollutants and environmental diseases. These reports will facilitate research on air pollutant exposure and health effects in the older population of South Korea. Moreover, life-course approaches investigating the adverse effects of air pollutants in older adults are needed. The results of these studies will highlight the urgent need for an emphasis on this topic in older populations.
However, older populations are heterogeneous, and individuals may have a wide variety of health conditions, which may result in differences in their resistance to the exposure and health effects of air pollutants.5,6) Researchers and policymakers discussing the impact of air pollutants should consider the following characteristics of older adults: (1) vague symptoms and atypical presentation even in known specific diseases that are easily misdiagnosed as a normal aging process and which delay the diagnosis of the worsening of chronic disease or newly-onset disease;7) (2) functional decline, including physical performance or cognition, as an early sign of health deterioration in older populations;8) (3) various aging specific symptoms and disorders known as geriatric syndromes, and their accumulation which facilitates the worsening vicious cycle in the health condition of older adults eventually leading to morbidity and mortality;9) and (4) multimorbidity and risk of polypharmacy, which increase the risk of adverse effects and obscure the judgment of exposure.10,11)
Air pollution exacerbates poor prognoses by increasing individuals’ susceptibility to diseases rather than causing direct harm to health or disease itself.12) For the reasons mentioned above, however, the effects of air pollutants on older populations cannot be judged simply by individual risk factors such as age, chronic disease, cardiovascular disease, and cognitive function. Unlike that in the general younger population, the health spectrum of the older population is varied. Even when exposed to chronic ambient air pollutants, vulnerable older individuals are more likely to have vague symptoms such as fatigue, dizziness, functional decline, and ultimately, a worsened quality of life owing to air pollutant exposure before physician diagnosis. In particular, it remains unclear if the conventional analytic method that assesses the impact of air pollutant exposure mainly based on several subtle cardiopulmonary or cognitive functions can distinguish between the effects of air pollutants and the aging phenomenon, which is eventually likely to underestimate its influence. Vulnerability in older adults can be described as a looped system formed by a linkage between vulnerable health factors;13) therefore, the conventional risk stratification system is unlikely to be effective in older adult populations. Similar to other several diseases, a unique evaluation and risk stratification system specialized for older populations are required.14-16)
With these concerns, our researchers believe that frailty, a valuable measure of the health status of older individuals, might be the most suitable marker for measuring the effects of air pollutants in older populations.17,18) This measure encompasses all age-related symptoms and disorders such as dementia, sarcopenia, insomnia, and falls, which can be used to estimate the possible effects. However, the timing and intensity of the effects on the domains are expected to vary greatly and consideration should be given to respiratory influences, nonspecific symptoms, and pathophysiology.2) Therefore, rather than the conventional frailty index, a targeted concept and definition of frailty, namely an “air-pollutant frailty index” that reflects both the specificity of the aging physiology and the conventional known health effects of air pollutant exposure, should be developed.16) As with human immunodeficiency virus,14) myelodysplastic syndrome,19) and systemic lupus erythematosus,15) this concept of a disease-specific frailty index is also likely to be effective in vulnerable young populations. This frailty concept will serve as a compass for future fine dust studies in older adults.

CONFLICT OF INTEREST DISCLOSURES

The researchers claim no conflicts of interest.

REFERENCES

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