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Ann Geriatr Med Res > Volume 20(3); 2016 > Article
Annals of Geriatric Medicine and Research 2016;20(3):131-136.
DOI:    Published online September 30, 2016.
The Effects of Low-Dose Bisphosphonate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Patients With Osteoporosis
Seo Young Lee, Kyoung Min Kim, Sung Hye Kong, Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Hak Chul Jang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongman, Korea.
Osteoporosis is commonly treated with bisphosphonates. These drugs promote osteoclast apoptosis, which suppresses bone resorption. However, the probability of side effects increases with long-term use of bisphosphonates. There are several reports in Asia that show comparable effects between low and conventional doses of bisphosphonates; however, such reports are lacking in Korea. Here, we report a case series of 7 patients with osteoporosis — all women aged over 70 years — who were treated with bisphosphonates administered every other week.
Patients who had been diagnosed with osteoporosis and treated with a less frequent dose of bisphosphonates at a tertiary university hospital from January 2010 to May 2016 were included in this study. Bone mineral density (BMD) was assessed at the baseline and at a 12-month interval after the first administration of low-dose bisphosphonates by using dual-energy X-ray absorptiometry. The bone turnover marker C-terminal telopeptide (CTX) was evaluated at 3, 6, and 12 months after the first administration.
After 12 months of treatment with a lower dose of bisphosphonates, BMD increased and CTX levels were suppressed. The mean change in BMD was 4.0% at the lumbar spine, 3.1% at the femur neck, and 1.5% at the total hip; CTX was suppressed by 34% at 3 months, 42% at 6 months, and 44% at the end of the treatment.
We found that low-dose bisphosphonate therapy improved BMD and suppressed bone turnover rates in elderly Korean women.
Key Words: Frail elderly, Bone mineral density, Bisphosphonates
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