J Korean Geriatr Soc Search

CLOSE


Ann Geriatr Med Res > Volume 16(4); 2012 > Article
Journal of the Korean Geriatrics Society 2012;16(4):200-205.
DOI: https://doi.org/10.4235/jkgs.2012.16.4.200    Published online December 31, 2012.
Differences of Regional Cerebral Blood Flow between Early Alzheimer's Disease and Parkinson's Disease Associated with Dementia on 99mTc-Hexamethyl Propylene Amine Oxime Perfusion Single Photon Emission Computed Tomography
Seung Hee Na, In Uk Song, Young Do Kim, Hyuin Ji Cho, Sung Woo Chung, Yong An Chung
1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. siuy@freechal.com
2Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
뇌 관류 Single Photon Emission Computed Tomography에서 초기 알쯔하이머병과 파킨슨병 치매에서의 뇌 영역별 혈류량의 차이
나승희1, 송인욱1, 김영도1, 조현지1, 정성우1, 정용안2
가톨릭대학교 인천성모병원 신경과1, 가톨릭대학교 인천성모병원 신경과2
Abstract
BACKGROUND
Alzheimer's disease (AD) and Parkinson's disease associated with dementia (PDD) are considered to be frequent types of cortical and subcortical dementia. Definitive diagnosis of neurodegenerative diseases is impossible without biopsy. Single photon emission computed tomography (SPECT) of the brain has long been used for years with cognitive disorders. Nevertheless, differential brain perfusion of patients with PDD and AD who exhibit mild dementia has not been reported. Therefore, we investigated the differences in the cerebral perfusional pattern using perfusion SPECT between mild AD and mild PDD to help clarify the diagnosis in the early stage of these dementias, since accurate diagnosis is crucial in decision regarding treatment, appropriate advice, management and prognosis.
METHODS
Thirty-one patients with mild PDD and 32 patients with mild probable AD were enrolled in this study. All subjects underwent 99mTc-hexamethyl propylene amine oxime perfusion SPECT and general neuropsychological tests, and these data including perfusion images were analyzed.
RESULTS
Perfusion SPECT showed hypoperfusion in frontal, parietal and temporal regions in both PDD and AD patients with mild dementia. Hypoperfusion in the occipital and cerebellar regions was significantly apparent in only PDD patients.
CONCLUSION
Comparison of mild PDD with mild AD showed a significantly decreased perfusion in the occipital and cerebellar region in patients with mild PDD. Cerebral perfusion in the occipital region and the cerebellum could be a crucial differential diagnostic method of these diseases in the early phase. Further studies are needed for a definitive conclusion.
Key Words: Parkinson's disease, Alzheimer's disease, Dementia, Perfusion single photon emission computed tomography
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 2 Crossref
  •    
  • 1,372 View
  • 15 Download
Related articles in
Ann Geriatr Med Res


ABOUT
ARTICLE & TOPICS
Article Category

Browse all articles >

TOPICS

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#401 Yuksam Hyundai Venturetel, 20, Teheran-ro 25-gil, Gangnam-gu, Seoul 06132, Korea
Tel: +82-2-2269-1039    Fax: +82-2-2269-1040    E-mail: agmr.editorial@gmail.com                

Copyright © 2024 by Korean Geriatrics Society.

Developed in M2PI

Close layer
prev next