| Coagulopathy Caused by Concurrent Ciprofloxacin and Warfarin Use: What Other Factors Induce Coagulopathy? |
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Sungmo Jung, Misung Park, Won Jin Kim, Chang Oh Kim |
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Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. cokim@yuhs.ac |
| 항응고요법 환자에서 사용한 Ciprofloxacin에 의해 유발된 응고장애에 관한 요인 분석 |
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정성모1, 박미성1, 김원진1, 김창오1 |
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연세대학교 의과대학 내과학교실 |
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| Abstract |
BACKGROUND
To assess factors affecting the prolongation of the international normalized ratio (INR) with concurrent warfarin and ciprofloxacin use.
METHODS
A retrospective case-control study was performed at a single, 2,000-bed tertiary hospital between January 2007 and December 2009. Thirty-three patients who were on warfarin and ciprofloxacin concurrently were enrolled. Demographics and clinical data were collected from medical records.
RESULTS
Nine patients were assigned to the case group (prolonged INR) and 19 patients to the control group (normal INR). Activities of daily living (ADL) and total number of classes of medications taken demonstrated significant differences between the groups (15.33 vs. 7.11, p<0.001; 7.11 vs. 5.47, p=0.041). No bleeding complications occurred during this study.
CONCLUSION
As ADL reflects patient performance status and general condition of an individual, we conclude that a poor general condition is associated with coagulopathy in persons concurrently using warfarin and ciprofloxacin. |
| Key Words:
Warfarin, International normalized ratio, Ciprofloxacin, Coagulopation disorders, Activities of daily living |
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