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Ann Geriatr Med Res > Volume 17(4); 2013 > Article
Journal of the Korean Geriatrics Society 2013;17(4):185-191.
DOI: https://doi.org/10.4235/jkgs.2013.17.4.185    Published online December 31, 2013.
Does the Incidence of Rhabdomyolysis Induced by Doxylamine Overdose Increase in the Elderly?
Yong Min Lim, Han Sung Choi, Oh Young Kwon, Jong Seok Lee, Hoon Pyo Hong, Young Gwan Ko, Seong Gwan Lim, Shin Chul Kim, Dong Pil Kim
1Department of Emergency Medicine, Kyung Hee University School of Medicine, Seoul,
2Department of Emergency Medicine, Dongsuwon General Hospital, Suwon, Korea
독시라민 중독 노인 환자에게서 횡문근융해증이
더 많이 발생하는가 ?
임용민1⦁최한성1⦁권오영1⦁이종석1⦁홍훈표1⦁고영관1⦁임성관2⦁김신철2⦁김동필2
경희대학교 의학전문대학원 응급의학교실1, 동수원병원 응급의학과2
Abstract
BACKGROUND
Doxylamine is an over-the-counter drug that is popular in the treatment of insomnia. Doxylamine is relatively safe but can cause rhabdomyolysis. The aim of this study was to evaluate whether the incidence of rhabomyolysis increased in elderly patients (age> or =65 years) with doxylamine overdose.
METHODS
This study included 108 patients admitted to an Emergency Department after doxylamine overdose between January 1, 2000, and March 31, 2013. Age, sex, time ingested before admission, amount of drug ingested, gastric lavage, tachycardia, vomiting, hematuria, blood urea nitrogen, blood creatinine, urine pH, and alcohol ingestion were investigated for the risk factors of rhabdomyolysis.
RESULTS
Forty-three patients (47.6%) developed rhabdomyolysis. Of 16 elderly patients, 11 developed rhabdomyolysis. Of the 92 patients <65 years-of-age, 34 developed rhabdomyolysis. Advanced age, alcohol ingestion, and increased blood creatinine level were significantly associated with the development of rhabdomyolysis.
CONCLUSION
In elderly patients with doxylamine overdose, the incidence rate of rhabdomyolysis may be increased. A high index of suspicion and evaluation of rhabdomyolysis is warranted in elderly patients with doxylamine overdose.
Key Words: Doxylamine, Rhabdomyolysis, Elderly
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