| Valacyclovir-Induced Neurotoxicity in a Maintenance Hemodialysis Patient |
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June Seong Hwang, Hyo Yoep Song, Hoon Gil Jo, Song I Lee, Byung Hun Lim, Jung Sub Song, Seon Ho Ahn |
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Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Korea. ashneph@wonkwang.ac.kr |
| 유지혈액투석 중인 환자에서 발생한 Valacyclovir 중추 신경계 독성 |
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황준성⦁송효엽⦁조훈길⦁이송이⦁임병훈⦁송정섭⦁안선호 |
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원광대학교 의과대학 내과학교실 |
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| Abstract |
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Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany the use of this drug, valacyclovir is increasingly used to treat herpes zoster, as it is more effective when orally administered. This paper reports one case of neurotoxicity of valacyclovir in patients with end stage renal disease who were undergoing maintenance hemodialysis. Valacyclovir can induce life-threatening neurotoxicity, especially in end stage renal disease patients despite the appropriate dose reduction. Furthermore, Valacyclovir-induced neurotoxicity can be effectively managed by intensive hemodialysis. |
| Key Words:
End-stage renal disease, Hemodialysis, Neurotoxicity, Valacyclovir |
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