| Pulmonary Cryptococcosis in Rheumatoid Arthritis Patient Treated With Leflunomide |
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Chang Kyoo Byon, Sang Woo Yim, Jun Yong Park, Mee Sook Roh, Sung Won Lee, Won Tae Chung, Sang Yeob Lee |
1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. leesy@dau.ac.kr
2Department of Pathology, Dong-A University College of Medicine, Busan, Korea. |
| 류마티스관절염 환자에서 레플루노마이드 사용 중 발생한 크립토코쿠스 폐렴 1예 |
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변창규1⦁임상우1⦁박준용1⦁노미숙2⦁이성원1⦁정원태1⦁이상엽1 |
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동아대학교 의과대학 내과학교실1, 병리학교실2 |
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| Abstract |
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Leflunomide, a disease-modifying antirheumatic drug, is effective for rheumatoid arthritis as monotherapy or combination therapy with methotrexate. The most common adverse effects are diarrhea, dyspepsia, nausea, abdominal pain, oral ulcer, hepatotoxicity, skin rash, hypertension, weight loss, and interstitial lung disease. The occurrence of pulmonary cryptococcosis in leflunomide treatment has not been reported in Korea. A 74-year-old woman was admitted to hospital due to asymptomatic pulmonary nodule. She was diagnosed rheumatoid arthritis and treated with leflunomide 5 months ago due to treatment failure with methotrexate, hydroxychloroquine, and sulfasalazine. Chest radiograph and computed tomography showed solitary pulmonary nodule in her right lower lung. Pulmonary cryptococcosis was confirmed by needle biopsy of lung stained with Gomori methenamine silver and mucicarmine. The lesion was improved after antifungal therapy for 3 months. |
| Key Words:
Cryptococcosis, Leflunomide, Rheumatoid arthritis |
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