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Journal of the Korean Geriatrics Society 2008;12(1):5-10.
Published online March 31, 2008.
Clinical Aspects of Genetic Testing for Dementia
Seung Hwan Lee, Kun Woo Park
1Department of Neurology, College of Medicine, Kangwon National University, Kangwon, Korea.
2Department of Neurology, College of Medicine, Korea University, Seoul, Korea. kunu@korea.ac.kr
치매관련 유전자 검사의 임상적 고찰
Abstract
Dementia is the progressive or chronic dysfunction of cortical or subcortical functions that results in complex cognitive decline and Alzheimer's disease is the most common etiology of dementia. Currently, causal genetic mutations such as amyloid precursor protein, presenilin 1, presenilin 2 in familial Alzheimer's disease and many susceptible genes including polymorphysm of apolipoprotein E have been reported. Furthermore, genetic testings are available in person at risk for Alzheimer's disease. However, besides from results of genetic testing, there are many issues such as economics, ethics, psychological and legal. So clinician should be considered these complexities before ordering genetic test for patients with/without Alzheimer's disease.
Key Words: Familial Alzheimer's disease, Causal genes, Susceptible gene, Issues


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