| Relationship between Neuropsychiatric Symptoms and Activities of Daily Living in Alzheimer's Disease |
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Seon Young Ryu, Sang Bong Lee, Tae Woo Kim, In Uk Song, Eun Young Oh, Hye Yeoung Choi |
1Department of Neurology, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea. streamlined@hanmail.net
2Department of Neurology, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea.
3Department of Clinical Psychology, Chungnam National University Graduate School, Daejeon, Korea. |
알츠하이머병에서 행동심리 증상이 일상생활수행능력에
미치는 영향 |
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선영1,이상봉1,김태우1,송인욱2,오은영1,최혜영3 |
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가톨릭대학교 의과대학 대전성모병원 신경과학교실1, 인천성모병원 신경과학교실2, 충남대학교 일반대학원 응용심리학과 임상심리3 |
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| Abstract |
BACKGROUND
In Alzheimer's disease (AD), cognitive impairment is associated with functional impairment; and neuropsychiatric symptoms are common in AD patients. However, there have been few studies about the relationship between neuropsychiatric symptoms and functional state in AD. The objective of this study is to investigate the effects of neuropsychiatric symptoms on activities of daily living in AD.
METHODS
We reviewed the medical records of 60 AD patients meeting the criteria of the Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) for probable AD (mean age, 75.4+/-7.0 years; 13 men, 47 women). The relationships between the Neuropsychiatric Inventory (NPI) and two functional measures, instrumental activities of daily living (IADL) and the Barthel Index, were analysed.
RESULTS
The total NPI score was significantly associated with both functional measures (IADL: r=0.543; Barthel Index: r=-0.515), as were the NPI subscale scores of delusion, hallucination, agitation, depression, anxiety, and irritability. Multivariate regression analyses showed that total NPI score and duration of dementia were significant predictive factors for both IADL and the Barthel Index. In addition, the total NPI score still significantly influenced the two functional measures after controlling for age, duration of dementia, and Mini-Mental State Examination.
CONCLUSION
The total NPI score was a significant predictive factor for functional status beyond the contribution of cognitive impairment in AD. Neuropsychiatric symptoms are associated with increased functional impairments in AD. Screening and management of neuropsychiatric symptoms during the course of AD would be helpful in improving functional status. |
| Key Words:
Neuropsychiatric symptoms, Activities of daily living, Alzheimer's disease |
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