| Relationship between Plasma Lipids and Osteoporosis in Korean Postmenopausal Women |
|
Kyung Shik Lee, Jae Hwan Cho, Chang Hae Park, Bo Seung Kim, Kyung Hwan Cho, Seung Hwan Lee, Byung Jun Ko, Do Hoon Kim |
1Department of Family Medicine, Gachon University of Medicine and Science, Incheon, Korea.
2Department of Family Medicine, Korea University College of Medicine, Seoul, Korea. kmcfm@hanmail.net |
| 한국 폐경 후 여성에서 골밀도와 혈중 지질과의 연관성 |
|
이경식1,조재환2,박창해2,김보승2,조경환2,이승환2,고병준2,김도훈2 |
|
|
|
|
| Abstract |
BACKGROUND
Recent studies have suggested associations between cardiovascular diseases (CVD) and osteoporosis and between serum lipids and osteoporosis. However, there are only a few studies about the relationship between bone mineral density (BMD) and serum lipids in Koreans. The aim of this study was to evaluate the correlation of serum lipid levels with osteoporosis in postmenopausal women in Korea.
METHODS
This cross-sectional study consisted of 1,093 Korean postmenopausal women who visited a university hospital for medical checkup from March 2007 to March 2009. Anthropometric measurements and blood tests were done for body mass index (BMI), plasma lipids, and fasting glucose. BMD was measured using a dual energy X-ray absorptiometry. Blood pressure was taken. After the subjects were classified into three groups (osteoporosis, osteopenia, or normal) by lumbar or femur BMD, the correlation between serum lipids and BMD was analyzed.
RESULTS
Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in the osteoporosis group (52.74+/-13.94 mg/dL) than in the other two groups (osteopenia, 56.22+/-13.40 mg/dL; normal, 56.54+/-13.22 mg/dL; p=0.007) when participants were grouped by lumbar BMD. In addition, serum triglyceride in the osteoporosis group was higher than in the other two groups. The results were statistically significant after adjusting for confounding factors including age, BMI and blood pressure. However, there was no significant difference when grouped by femur BMD.
CONCLUSION
With decreasing lumbar BMD, we saw lower HDL-C levels and higher triglyceride levels. Osteoporosis may play a role as a risk factor for CVD through its relationships with lumbar BMD and serum lipids. |
| Key Words:
Osteoporosis, Postmenopausal women, Bone mineral density, High-density lipoprotein cholesterol, Triglycerides |
|
PDF Links
Full text via DOI
Download Citation
