Effect of Thyroid Stimulating Hormone on Prognosis of Elderly Angina Patients

Yun, Kyeong Ho; Oh, Seok Kyu; Choi, Jun Ho; Song, Mi Jin; Park, Eun Mi; Kim, Yun Kyung; Rhee, Sang Jae; Yoo, Nam Jin; Kim, Nam Ho; Jeong, Jin Won

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Original Article

Journal of the Korean Geriatrics Society 2006;10(3):161-166.
Published online September 30, 2006.

Effect of Thyroid Stimulating Hormone on Prognosis of Elderly Angina Patients

Kyeong Ho Yun, Seok Kyu Oh, Jun Ho Choi, Mi Jin Song, Eun Mi Park, Yun Kyung Kim, Sang Jae Rhee, Nam Jin Yoo, Nam Ho Kim, Jin Won Jeong

Department of Cardiovascular Medicine, Wonkwang University College of Medicine, Iksan, Korea. oskcar@wonkwang.ac.kr

노인 협심증 환자에서 갑상선 자극 호르몬이 예후에 미치는 영향

Abstract

BACKGROUND
It was not established whether a normal range of thyroid stimulating hormone (TSH) influences the presence and outcome of coronary atherosclerosis. We evaluated that the effect of TSH level on prognosis of elderly angina patients who have normal thyroid function.
METHODS
We studied 166 angina patients (70.8+/-4.02 years, male 43.4%) who underwent elective coronary angiography. TSH, free thyroxine, serum lipid levels and high-sensitivity C-reactive protein levels were measured before coronary angiography. According to TSH level, the patients divided into two groups; patients with high level of TSH (> or =2.5 microIU/mL) and low level of TSH (<2.5 microIU/mL). Laboratory findings and 1 year major adverse cardiac events (MACE) were compared between the two groups.
RESULTS
Serum creatinine levels were significantly higher in patients with high TSH level (p=0.048). A significant correlation was observed between the levels of TSH and triglyceride level and creatinine level (r=0.704 and 0.512, respectively, p<0.05). MACE occurred in 5.1% of patients with higher TSH and 16.7% of patients with lower TSH (p=0.034). The multivariate analysis revealed that creatinine (OR 5.33, p=0.012) and TSH (OR 1.46, p=0.042) were independent predictors for MACE.
CONCLUSIONS
The high level of serum TSH is associated with poor outcome in elderly angina patients with normal range of thyroid function.

Key Words: Thyroid gland, Angina, Outcome

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