| Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly |
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Chang Hyung Hong, Hae Kwan Cheong, Eun A Kim, Kang Soo Lee, Kyung Ran Kim, Kyung Ryeol Cha, Ji Hey Choi, Byoung Hoon Oh |
1Department of Psychiatry, College of Medicine, Yonsei University College of Medicine, Korea. drobh@chollian.net
2Institution of Behavioral Science in Medicine, Yonsei University College of Medicine, Korea.
3Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Korea.
4Center for Occupational Disease Research, Occupational Safety and Health Research Institute, Korea.
5Severance Mental Health Hospital, Yonsei University College of Medicine, Korea. |
| 노인에서 ApoE 유전자형이 영양 위험도와 인지기능에 미치는 영향 |
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| Abstract |
BACKGROUND
The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community.
METHODS
A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping.
RESULTS
649 subjects (65.2%) were on good nutritional state (NSI score < or = 2) and 347 subjects (34.8%) were on moderate or high nutritional risk (NSI score > or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77).
CONCLUSION
These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele. |
| Key Words:
Nutrition, NSI checklist, K-MMSE, Elderly, ApoE genotyping |
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