A Case of Pseudomembranous Aspergillus Tracheobronchitis in a Patient with Diabetes Mellitus

Yi, Young Arm; Kim, Jong Min; Hwang, Se Jin; Sung, Shi Jung; Kim, Se Jin; Kim, Young Min; Seo, Kwang Won; Ra, Seung Won; Jegal, Yangjin

doi:2010.14.1.42

Ann Geriatr Med Res > Volume 14(1); 2010 > Article

Case Report

Journal of the Korean Geriatrics Society 2010;14(1):42-47.
DOI: https://doi.org/10.4235/jkgs.2010.14.1.42 Published online March 31, 2010.

A Case of Pseudomembranous Aspergillus Tracheobronchitis in a Patient with Diabetes Mellitus

Young Arm Yi, Jong Min Kim, Se Jin Hwang, Shi Jung Sung, Se Jin Kim, Young Min Kim, Kwang Won Seo, Seung Won Ra, Yangjin Jegal

¹Department of Internal Medicine, University of Ulsan, College of Medicine, Ulsan, Korea. yjjegal@uuh.ulsan.kr
²Department of Pathology, University of Ulsan, College of Medicine, Ulsan, Korea.

당뇨병 환자에서 발생한 거짓막 아스페르길루스 기관기관지염 1예

이영암¹ㆍ김종민¹ㆍ황세진¹ㆍ성시정¹ㆍ김세진¹ㆍ김영민²ㆍ서광원¹ㆍ나승원¹ㆍ제갈양진¹

울산대학교 의과대학 내과학교실¹, 병리학교실²

Abstract

Aspergillus tracheobronchitis is one form of invasive pulmonary aspergillosis which is characterized by ulcers and pseudomembrane formation in tracheobronchial tree. In Aspergillus tracheobronchitis, the infection is often limited to the mucosa and it accounts for less than 10 percents of invasive disease. Invasive aspergillosis mainly occurs in immunocompromized patients with prolonged neutropenia, advanced AIDS, organ transplantation, high-dose glucocorticoid therapy or cytotoxic therapy although it can occur in less immunocompromised patients, such as after influenza, COPD, old age, and diabetes. We report a case of Aspergillus tracheobronchitis in a 61 year-old patient with diabetes and Child Pugh class A liver cirrhosis. He presented with cough and purulent sputum for 10 days. He was diagnosed by bronchoscopy and successfully treated with antifungal therapy.

Key Words: Invasive pulmonary aspergillosis, Bronchitis, Diabetes mellitus