| Skeletal Muscle Mass in Elderly Heart Failure Patients; Comparison between Systolic and Diastolic Heart Failure and Corresponding Significance in Exercise Capacity |
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Kwang Il Kim, Si Young Park, Hyun Jung Yoo, Suhyun Chung, Ye Won Suh, Soo Lim, Ki Woong Kim, Hak Chul Jang, Cheol Ho Kim |
1Seoul National University Bundang Hospital, Seongnam, Korea. kikim907@snu.ac.kr
2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. |
| 노인 심부전 환자의 골격근량과 운동능력의 특성 비교 |
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김광일1,2, 박시영1, 유현정1, 정수현1, 서예원1, 임수1,2, 김기웅1,3, 장학철1,2, 김철호1,2 |
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1분당서울대학교병원, 2서울대학교의과대학 내과학교실, 3서울대학교의과대학 정신과학교실 |
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| Abstract |
BACKGROUND
Exercise intolerance is a common symptom of heart failure and has a detrimental impact on the quality of life. Skeletal muscle atrophy has been considered an important contributor to exercise intolerance; however, most studies have been conducted in patients with advanced systolic heart failure.
METHODS
We studied 39 ambulatory heart failure patients (age, 77.9+/-6.5; male, 17 [43.6%]) and 39 age and gender-matched, community-dwelling, elderly subjects. Clinical, laboratory, and echocardiographic evaluations were performed. Dual-energy X-ray absorptiometry was performed to assess the body composition. Exercise capacity was measured by a six-minute walk test. Comprehensive geriatric assessments were also performed to evaluate comorbidity, medication, physical function, cognitive function, and nutritional status.
RESULTS
Skeletal muscle mass of heart failure patients showed no differences when compared with that of age- and gender-matched control subjects in any part of the body or in the whole body. Although diastolic heart failure patients showed lower levels of skeletal muscle mass than systolic heart failure patients, no significant difference was identified in either systolic or diastolic heart failure patients compared with respective age- and gender-matched control groups. The six-minute walk distances showed no difference between the groups (257.2+/-117.8 m in the diastolic heart failure group versus 302.7+/-109.4 m in the systolic heart failure group, p=0.226).
CONCLUSION
Although skeletal muscle mass has been known to be an independent factor associated with exercise capacity in advanced heart failure patients, skeletal muscle mass was not decreased in ambulatory, elderly heart failure patients when comparing age- and gender-matched control subjects. |
| Key Words:
Heart failure, Elderly, Skeletal muscle, Geriatric assessment |
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