| Clinicopathological Features of Gastric Carcinoma in the Korean Elderly |
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Byeong Cheol Song, Jae Won Choi, Won Beom Choi, Kwang Hee Yoon, Yeon Ho Joo, Kwang Ro Joo, Hwoon Yong Jung, Suk Kyun Yang, Hae Ryun Kim, Young Soo Lee, Weon Seon Hong, Young Il Min |
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Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea |
| 한국 노인위암의 임상 및 병리학적 특징 |
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| Abstract |
BACKGROUND
Gastric carcinoma is the leading cause of cancer death in Korea. Although the incidence of gastric carcinoma has the tendency to increase in recent years with the increase in the elderly in Korea, clinicopathological characteristics of gastric carcinoma in the elderly has not been studied in detail yet. This study was undertaken to investigate the clinicopathological features of gastric carcinoma in the Korean elderly.
METHODS
The clinicopathological data, such as age, gender, cancer location, macroscopic appearance, histopathology, depth of invasion, lymph node metastasis, distant metastasis, stage, and type of operation, were retropectively reviewed from the hospital records of 682 patients with gastric adenocarcinoma admitted to the Asan Medical Center from Jan. 1996 to Dec. 1996. In 581 patients treated with gastrectomy, the postoperative findings were used in analysis, while in 101 patients receiving no operation due to mestastasis, clinical and laboratory findings were used. All patients were divided into three groups: the young; 39 years of age or younger, the middle-aged; between 40 and 64 years old, and the elderly; 65 years old or over.
RESULTS
A total of 183(26.8%) of 682 patients were in the elderly, while 91(13.3%) and 408(59.8%) were in the young and middle-aged, respectively. The gender ratio for male to female was 2.3: 1 in the elderly, which was not different from that the young or middle-aged. In the elderly patients, as compared with the young or middle-aged, the antral involvement, well and moderately differentiated adenocarcinoma, Borrmann type I and II, and stage IV were more frequent, and the rate of early gastric cancer was less common. There was no significant difference in the depth of invasion, lymph node metastasis, distant metastasis and type of operation between three groups.
CONCLUSION
Some of the clinicopathological features of gastric adenocarcinoma in the elderly are different from those of the young or middle-aged, and in consequence these differences should be considered in the management and study of the elderly patients with gastric carcinoma. |
| Key Words:
Gastric carcinoma, The elderly, Clinicopathological features |
| 초 록 |
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방법 : 1996년 1월부터 12월까지 서울중앙병원에 입원하여 위선암으로 진단 받았던 682명을 대상으로 후향적으로 연구하였다. 이중 위절제술을 받는 581명은 수술소견을 중심으로 평가하였고 근치적 수술이 불가능하였던 101명은 임상 및 검사소견을 중심으로 평가하는데, 모든 환자는 나이에 따라 3군으로 분류하여 비교하였다. 결과 : 노인위암은 전체 위암환자 682명중 183명(26.8%)였고, 약년층은 91명(13.3%), 장년층은408명(59.8%)이었다. 노인층에서의 남녀비는 2.3 : 1로 장년층 및 약년층과 차이가 없었다. 노인위암은 장년층 또는 약년층의 위암과 비교할 때 전정부에 호발하고, 조기위암의 빈도가 낮고, Borrmann type Ⅰ과 Ⅱ인 국한령이 많으며, 고분화암인 well differentiated type과 moderately differentiated type이 높으며, stage Ⅳ가 많았다. 그러나 암의 침윤도, 림프절 전이, 원격전이와 수술방법은 3군 사이 유의한 차이가 없었다. 결론 : 노인위암은 여러 임상 및 병리학적 특징이 장년층 또는 약년층 위암과 차이가 있음이 관찰되는데, 이러한 차이는 향후 노인위암의 임상 진료와 연구시 신중히 고려해야 할 요인으로 사료된다. |
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