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Ann Geriatr Med Res  <  Volume 23(1); 2019 <  Articles

Ann Geriatr Med Res 2019; 23(1): 3-8  https://doi.org/10.4235/agmr.19.0001
Intermuscular Adipose Tissue: A Brief Review of Etiology, Association With Physical Function and Weight Loss in Older Adults
Debra Lynn Waters
Department of Medicine and School of Physiotherapy, University of Otago, Dunedin, New Zealand
Correspondence to: Debra Lynn Waters, PhD, https://orcid.org/0000-0001-7982-2370
Department of Medicine and School of Physiotherapy, University of Otago, PO Box 56 Dunedin 9054, New Zealand, E-mail: debra.waters@otago.ac.nz
Received: January 4, 2019; Revised: January 26, 2019; Accepted: January 26, 2019; Published online: March 31, 2019.
© The Korean Geriatrics Society. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Adipose tissue redistributes during aging resulting in increased intermuscular adipose tissue (IMAT), intramuscular, and intramyocellular lipid while subcutaneous fat decreases. IMAT has been associated with lower muscle strength, power, and quality, chronic inflammation, impaired glucose tolerance, and elevated total cholesterol in older adults. This review focused on trials investigating the role of age, physical activity and diet on IMAT. The studies agreed that IMAT increases with age and seems to be responsive to physical activity, particularly the combination of aerobic and resistance exercise. However, some reported this could occur with or without weight loss, and some reported that high IMAT at baseline may blunt the muscle quality adaptive response to physical training. Larger and longer trials are needed to differentiate the independent or synergistic effects of resistance and/or aerobic training, and obesity and weight loss combined with resistance, aerobic or combination of aerobic and resistance training on IMAT.
Keywords: Adipose tissue, Skeletal muscle, Weight loss, Aging


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