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Ann Geriatr Med Res  <  Volume (); 1999 <  Articles

Annals of Geriatric Medicine and Research  
Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Long-term Follow-up
Soo-Jin Cho1, Byung-Kun Kim2, Byung-Su Kim3, Jae-Moon Kim4, Soo-Kyoung Kim5, Heui-Soo Moon6, Myoung-Jin Cha7, Kwang-Yeol Park8, Jong-Hee Sohn9, Min Kyung Chu10, Tae-Jin Song11
1Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
2Department of Neurology, Eulji University School of Medicine, Seoul, Korea
3Department of Neurology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea
4Department of Neurology, Chungnam National University College of Medicine, Daejeon, Korea
5Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea
6Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
7Department of Neurology, National Police Hospital, Seoul, Korea
8Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
9Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea
10Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
11Department of Neurology, Ewha Womans University College of Medicine, Seoul, Korea
Correspondence to: Tae-Jin Song, MD, PhD
Department of Neurology, Ewha Womans University College of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea
Tel: +82-2-2650-2677
Fax: +82-2-2650-5958
E-mail: knstar@ewha.ac.kr
Received: August 20, 2018; Revised: October 8, 2018; Accepted: October 25, 2018; Published online: December 26, 2018.
© The Korea Geriatrics Society. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction. Methods: We prospectively enrolled 125 older (≥ 65 years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes. Results: The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28-34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28-12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00-1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01-1.11; p=0.011). Conclusion: Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache.
Keywords: Migraine disorders, Tension-type headache, Elderly headache, Cardiovascular diseases, Cognitive dysfunction

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