Ann Geriatr Med Res 2017; 21(1): 10-16  http://dx.doi.org/10.4235/agmr.2017.21.1.10
Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction
Namkyun Kim1, Hun Sik Park1, Jae Yong Yoon1, Hyun Jun Cho1, Chang-Yeon Kim1, Jae-Hyung Roh1, Myung Hwan Bae1, Jang Hoon Lee1, Dong Heon Yang1, Yongkeun Cho1, Shung Chull Chae1, Jihyun Sohn2, Se Yong Jang2
1Department of Internal Medicine, 2Cardioloy Center, Kyungpook National University Hospital, Daegu, Korea
Correspondence to: Hun Sik Park, MD
Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
Tel: +82-53-420-5529 Fax:+82-53-424-6721 E-mail: hspark@knu.ac.kr
Received: November 28, 2016; Revised: February 7, 2017; Accepted: February 11, 2017; Published online: March 31, 2017.
© The Korea Geriatrics Society. All rights reserved.

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Abstract
Background: The aim of this study was to investigate the predictive value of estimated glomerular filtration rate (eGFR) calculated with the simplified Modification of Diet in Renal Disease (MDRD) Study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for prognosis in elderly patients with acute myocardial infarction (AMI). Methods: This study included 1,372 patients (mean age, 64.2±11.8 years; men, 67.9%) entered in the Kyungpook National University Hospital Acute Myocardial Infarction Registry from November 2005 to February 2010. We analyzed 1-year major adverse cardiac events (MACE) according to the eGFR calculated with the simplified MDRD Study and CKD-EPI equations. Results: The mean eGFR values calculated with the MDRD Study and CKD-EPI equations were 81.3±44.4 and 78.5±27.1 mL/(min/1.73 m2), respectively. In receiver operating characteristic curve analysis for prediction of 1-year MACE, the area under the curve based on the CKD-EPI equation was greater than that using the MDRD Study equation (CKD-EPI equation vs. MDRD Study equation: 0.691 vs. 0.674, p=0.041). Multivariate analysis using a Cox proportional hazards model revealed that the eGFR calculated with the CKD-EPI equation was an independent predictor of the occurrence of MACE within 1 year after AMI. However, eGFR calculated with the MDRD Study equation did not have predictive value. Furthermore, the eGFR calculated with the CKD-EPI equation had incremental prognostic value for established risk factors (chi-square=5.78, p=0.016). Conclusion: The eGFR calculated using the CKD-EPI equation was an independent predictor of 1-year MACE in elderly patients with AMI.
Keywords: Myocardial infarction, Glomerular filtration rate, Major adverse cardiac event


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