Ann Geriatr Med Res 2016; 20(4): 168-176  http://dx.doi.org/10.4235/agmr.2016.20.4.168
Microbiota: A Key for Healthy Aging
Yoon Jin Choi1, Dong Ho Lee1,2
1Department of Internal Medicine and Seoul National University Bundang Hospital, Seongnam, 2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
Correspondence to: Dong Ho Lee, MD, PhD 
Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam 13620, Korea 
Tel: +82-31-787-7008 
Fax:+82-31-787-4051 
E-mail: dhljohn@yahoo.com
Received: October 24, 2016; Revised: October 26, 2016; Accepted: December 16, 2016; Published online: December 31, 2016.
© The Korea Geriatrics Society. All rights reserved.

Abstract
A growing body of literature has suggested that changes in the composition of gut microbiota could be associated with age-related processes. Significant changes in the gastrointestinal microbiota in the elderly have been reported according to diet, drug use, and place of residence. Moreover, changes in microbiota composition in old age have been associated with immunosenescence and inflammatory processes that are pathophysiological mechanisms involved in frailty. A better understanding of the possible reasons for changes in gut microbiota in the elderly and the impact of these changes on health could be a basis for maintaining healthy gut function and healthy aging in the present situation with an increasing elderly population.
Keywords: Microbiota, Bifidobacterium, Aging, Frailty, Elderly


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